Uni Basel Research Database

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Search results for publications (keywords "beat ernst"")

Showing records 1 - 20 (of 145)

Publication: Authored Book (Verfasser eines eigenständigen Buches)

Author	Year	Title	Abstract	Publisher	Affiliated organization
Vögtli, Alexander; Ernst, Beat	2010	Moderne Pharmakokinetik : Transport durch Membranen	Im Rahmen einer biopharmazeutischen Synopse erläutert es mit den physikochemischen Eigenschaften verschiedener Arzneistoffmoleküle in Zusammenhang stehende Aspekte der Arzneimittelwirkung, die anderswo kaum auf diesem eingängigen und leicht verständlichen Niveau beschrieben sind. Die Autoren verstehen es zu abstrahieren und den Leser durch eine Vielzahl konkreter Beispiele bei...	Wiley-VCH Verlag	Departement Pharmazeutische Wissenschaften / Molekulare Pharmazie (Ernst)

Publication: Book Item (Buchkap., Lexikonartikel, jur. Kommentierung, Beiträge in Sammelbänden etc.)

Author	Year	Title	Abstract	Publisher	Affiliated organization
Stöckli, Andreas; Studer, M.; Cutting, Brian; Ernst, Beat	2009	Interpretation of 13C-NMR spectra by artificial neural network techniques (NeuroCarb)		Wiley-Blackwell	Departement Pharmazeutische Wissenschaften / Molekulare Pharmazie (Ernst)
Pang, Lijuan; Bezençon, Jacqueline; Kleeb, Simon; Rabbani, Said; Sigl, Anja; Smiesko, Martin; Sager, Christoph P.; Eris, Deniz; Schwardt, Oliver; Ernst, Beat	2017	FimH antagonists - solubility vs. permeability	Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) are among the most prevalent infections worldwide. Since frequent antibiotic treatment favors the emergence of antibiotic resistance, efficient non-antibiotic strategies are urgently needed. The first step of the pathogenesis of UTI is the bacterial adherence to urothelial host cells, a process mediated by the...	Royal Society of Chemistry	Departement Pharmazeutische Wissenschaften / Molekulare Pharmazie (Ernst)
Carere-Sigl, Anja; Nowakowska, Justyna; Hevey, Rachel; Khanna, Nina; Ernst, Beat;	2021	FimH antagonists prevent biofilm formation on catheter surfaces	In many fields, most notably medicine and molecular biology, the understanding of the structure and function of carbohydrates and glycoconjugates remains vital. This new volume contains critical reviews covering the latest findings in both chemical and biological sciences, and demonstrates the interdisciplinary nature of modern carbohydrate research. This book addresses diverse applications that...	The Royal Society of Chemistry	Departement Pharmazeutische Wissenschaften / Molekulare Pharmazie (Ernst)

Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)

Author	Year	Title	Abstract	Publisher	Affiliated organization
K. Lichtsteiner, Salome; Vögtli, Alexander; Weber, Christina; Burkhart, Helmar; Rizzotti, Sven; Folkers, Gerd; Khov-Tran, Van Van; Neier, Reinhard; Ernst, Beat	2003	Pharmasquare (Pharma²)		Chimia	Departement Mathematik und Informatik / High Performance and Web Computing (Burkhart), Departement Pharmazeutische Wissenschaften / Molekulare Pharmazie (Ernst)
Ernst, Beat; Magnani, John	2009	From carbohydrate leads to glycomimetic drugs	Carbohydrates are the most abundant natural products. Besides their role in metabolism and as structural building blocks, they are fundamental constituents of every cell surface, where they are involved in vital cellular recognition processes. Carbohydrates are a relatively untapped source of new drugs and therefore offer exciting new therapeutic opportunities. Advances in the functional...	Nature Reviews. Drug Discovery	Departement Pharmazeutische Wissenschaften / Molekulare Pharmazie (Ernst)
Magnani, John L.; Ernst, Beat	2009	Glycomimetic Drugs : A New Source of Therapeutic Opportunities	Carbohydrates are ubiquitous and represent the most abundant class of molecules in nature. All cell surfaces are coated with complex carbohydrates where they act as recognition molecules for other cells, functional molecules, and pathogens. Consequently, they are involved in disease indications as diverse as inflammation, cancer, and infectious disease. In general, native carbohydrates lack the...	Discovery Medicine	Departement Pharmazeutische Wissenschaften / Molekulare Pharmazie (Ernst)
Rabbani, Said; Corona, Francesco; Ernst, Beat	2009	Biochemical Characterization of Helicobacter pylori a-1-4 Fucosyltransferase : Metal Ion Requirement, Donor Substrate Specificity and Organic Solvent Stability	The effect of metal ions on the activity, the donor substrate specificity, and the stability in organic solvents of Helicobacter pylori alpha-1,4 fucosyltransferase were studied. The recombinant enzyme was expressed as soluble form in E. coli strain AD494 and purified in a one step affinity chromatography. Its activity was highest in cacodylate buffer at pH 6.5 in the presence of 20 mM Mn(2+) ions...	Biometals	Departement Pharmazeutische Wissenschaften / Molekulare Pharmazie (Ernst)
Knecht, Steven; Ricklin, Daniel; Eberle, Alex N; Ernst, Beat	2009	Oligohis-tags : mechanisms of binding to Ni2+-NTA surfaces	Since immobilized metal ion affinity chromatography (IMAC) was first reported, several modifications have been developed. Among them, Ni(2+) immobilized by chelation with nitrilotriacetic acid (NTA) bound to a solid support has become the most common method for the purification of proteins carrying either a C- or N-terminal histidine (His) tag. Despite its broad application in protein...	Journal of Molecular Recognition	Departement Biomedizin / Department of Biomedicine, University Hospital Basel, Departement Pharmazeutische Wissenschaften / Molekulare Pharmazie (Ernst)
Spreafico, Morena; Ernst, Beat; Lill, Markus A.; Smiesko, Martin; Vedani, Angelo	2009	Mixed-Model QSAR at the Glucocorticoid Receptor: Predicting the Binding Mode and Affinity of Psychotropic Drugs	The glucocorticoid receptor (GR) is a member of the nuclear receptor superfamily that affects immune response, development, and metabolism in target tissues. Glucocorticoids ore widely used to treat diverse pathophysiological conditions, but their clinical applicability is limited by side effects. A prediction of the binding affinity toward the GR would be beneficial for identifying...	ChemMedChem	Departement Pharmazeutische Wissenschaften / Molekulare Pharmazie (Ernst)
Peristera, Ourania; Spreafico, Morena; Smiesko, Martin; Ernst, Beat; Vedani, Angelo.	2009	Mixed-model QSAR at the human mineralocorticoid receptor : Predicting binding mode and affinity of anabolic steroids	We present a computational study on the human mineralocorticoid receptor (hMR) that is based on multidimensional quantitative structure-activity relationships (mQSAR). Therein, we identified the binding mode of 48 steroid and non-steroid homologues by flexible docking to the crystal structure (software Yeti) and quantified it using 6D-QSAR (software Quasar). The receptor surrogate, evolved using a...	Toxicology Letters	Departement Pharmazeutische Wissenschaften / Molekulare Pharmazie (Ernst)
Su, Z.; Wagner, Bea; Cocinero, E. J.; Ernst, Beat; Simons, J.	2009	The intrinsic conformation of a Lewis antigen : The Lewisx trisaccharide		Chemical Physics Letters	Departement Pharmazeutische Wissenschaften / Molekulare Pharmazie (Ernst)
Schwardt, Oliver; Gäthje, Heiko; Vedani, Angelo; Mesch, Stefanie; Gao, Gan-Pan; Spreafico, Morena; von Orelli, Johannes; Kelm, Sørge; Ernst, Beat	2009	Examination of the biological role of the a(2-6)-linked sialic acid in gangliosides binding to the myelin-associated glycoprotein (MAG)	The tetrasaccharide 1, a substructure of ganglioside GQ1b alpha, shows a remarkable affinity for the myelin-associated glycoprotein (MAG) and was therefore selected as starting point for a lead optimization program. In our search for structurally simplified and pharmacokinetically improved mimics of 1, modifications of the core disaccharide, the alpha(2 -> 3)- and the alpha(2 -> 6)-linked sialic...	Journal of Medicinal Chemistry	Departement Pharmazeutische Wissenschaften / Molekulare Pharmazie (Ernst)
Stokmaier, Daniela; Khorev, Oleg; Böni, F.; Gentner, M.; Cutting, Brian; Born, Rita; Schwingruber, K.; Ernst, T. O. G.; Wittwer, Matthias; Ricklin, Daniel; Spreafico, Morena; Vedani, Angelo; Rabbani, Said; Schwardt, Oliver; Ernst, Beat	2009	Design, synthesis and evaluation of monovalent ligands for the asialoglycoprotein receptor (ASGP-R)	A series of novel aryl-substituted triazolyl D-galactosamine derivatives was synthesized as ligands for the carbohydrate recognition domain of the major subunit H1 (H1-CRD) of the human asialoglycoprotein receptor (ASGP-R). The compounds were biologically evaluated with a newly developed competitive binding assay, surface plasmon resonance and by a competitive NMR binding experiment. With compound...	Bioorganic & Medicinal Chemistry	Departement Pharmazeutische Wissenschaften / Molekulare Pharmazie (Ernst)
Perchuc, A. M.; Menin, L.; Favreau, P.; Bühler, B.; Bulet, P.; Schöni, R.; Wilmer, M.; Ernst, Beat; Stöcklin, R.	2010	Isolation and characterization of two new Lys49 PLA2s with heparin neutralizing properties from Bothrops moojeni snake venom	Among the proteins and peptides already characterized in Bothrops moojeni venom, two novel phospholipases A(2) (PLA(2)) have been purified and fully sequenced by ESI-MS/MS techniques. Both of them belong to the enzymatically non-active Lys49 variants of PLA(2). They consist of 122 amino acids and share a characteristic sequence in their C-terminal region composed of clusters of basic amino acids...	Toxicon	Departement Pharmazeutische Wissenschaften / Molekulare Pharmazie (Ernst)
Chang, J.; Patton, J. T.; Sarkar, A.; Ernst, Beat; Magnani, J. L.; Frenette, P. S.	2010	GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice	Leukocyte adhesion in the microvasculature influences blood rheology and plays a key role in vaso-occlusive manifestations of sickle cell disease. Notably, polymorphonuclear neutrophils (PMNs) can capture circulating sickle red blood cells (sRBCs) in inflamed venules, leading to critical reduction in blood flow and vasoocclusion. Recent studies have suggested that E-selectin expression by...	Blood	Departement Pharmazeutische Wissenschaften / Molekulare Pharmazie (Ernst)
Dutzler, R.; Ernst, Beat; Hediger, M. A.; Keppler, D.; Mohr, P.; Neidhart, W.; Märki, H. P.	2010	Channels and transporters		Chimia	Departement Pharmazeutische Wissenschaften / Molekulare Pharmazie (Ernst)
Demler, C.; Bühler, B.; Menin, L.; Stöcklin, R.; Wilmer, M.; Ernst, Beat; Perchuc, A. M.	2010	Platelet-active substances in the venom of Bothrops moojeni snake : a novel evaluation method using whole blood aggregometry	The objective of the present study was an investigation of the crude Bothrops moojent venom, aiming at the identification of new compounds with platelet-activating or -inhibiting activity. The venom was separated by gel filtration chromatography into 18 fractions, which were tested by means of whole blood aggregometry for their activities affecting the aggregation of blood platelets. In order to...	Platelets	Departement Pharmazeutische Wissenschaften / Molekulare Pharmazie (Ernst)
Duthaler, R. O.; Ernst, B.; Fischer, R.; Katopodis, A. G.; Kinzy, W.; Marterer, W.; Oehrlein, R.; Streiff, M. B.; Thoma, G.	2010	In vivo Neutralization of naturally Existing Antibodies against Linear (1,3)-Galactosidic Carbohydrate Epitopes by Multivalent Antigen Presentation : a Solution for the First Hurdle of Pig-to-Human Xenotransplantation	Pig-to-human xenotransplantation of islet cells or of vascularized organs would offer a welcome treatment alternative for the ever-increasing number of patients with end-stage organ failure who are waiting for a suitable allograph. The main hurdle are preexisting antibodies, most of which are specific for 'Linear-B', carbohydrate epitopes terminated by the unbranched Gal-alpha(1,3)Gal...	Chimia	Departement Pharmazeutische Wissenschaften / Molekulare Pharmazie (Ernst)
Rabbani, Said; Jiang, Xiaohua; Schwardt, Oliver; Ernst, Beat	2010	Expression of the Carbohydrate Recognition Domain of FimH and Development of a Competitive Binding Assay	Uropathogenic Escherichia coli (UPEC) is the primary cause of urinary tract infections (UTIs). In the first step of this infective process, the virulence factor FimH located on type 1 pili allows UPEC to specifically adhere to oligosaccharides, which are part of glycoproteins on the urinary bladder mucosa. This initial step prevents the clearance of E. coli from the urinary tract and enables the...	Analytical Biochemistry	Departement Pharmazeutische Wissenschaften / Molekulare Pharmazie (Ernst)

Showing records 1 - 20 (of 145)

06/05/2024

Research Database / FORSCHUNGSDATENBANK